Liang Fang

Liang Fang

Research Associate Professor

Research Interests

1) Study gene regulation in cancer stem cells and EMT process at transcription and post-transcription levels

2) Identify functional genes involved in signaling pathways using CRISPR/Cas9-based genetic screen

3) Study tumor evolution and microenvironment using organoid culture and single-cell RNA-seq

Professional Experience

2017-present Research Assistant Professor, Southern University of Science and Technology

2013-2017 Postdoc, Max Delbrück Center for Molecular Medicine

2007-2008 Research Assistant, Charité University Medicine


2013 Ph.D. (Cell Biology), Humboldt University of Berlin

2007 M.Sc. Med. (Pharmacology), Zhejiang University

2005 B.Sc. Med. (Pharmaceutical Sciences) & B.Sc. (Biotechnology), Zhejiang University

Selected Publication

  1. ZHU, Q.*, FANG, L.*, HEUBERGER, J., KRANZ, A., SCHIPPER, J., SCHECKENBACH, K., VIDAL, R. O., SUNAGA-FRANZE, D. Y., MULLER, M., WULF-GOLDENBERG, A., SAUER, S. & BIRCHMEIER, W. 2019. The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Rep, 26, 415-428 e5.
  2. WENG, Q., WANG, J., WANG, J., WANG, J., SATTAR, F., ZHANG, Z., ZHENG, J., XU, Z., ZHAO, M., LIU, X., YANG, L., HAO, G., FANG, L., LU, Q. R., YANG, B. & HE, Q. 2018. Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization. Cell Death Dis, 9, 251.
  3. SCHAEFKE, B., SUN, W., LI, Y. S., FANG, L. & CHEN, W. 2018. The evolution of posttranscriptional regulation. Wiley Interdisciplinary Reviews-Rna, 9, e1485.
  4. QI, X., LI, Y., ZHANG, Y., XU, T., LU, B., FANG, L., GAO, J., YU, L., ZHU, D. & YANG, B. 2018. KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells. Acta pharmacologica Sinica.
  5. FANG, L., ZHU, Q., NEUENSCHWANDER, M., SPECKER, E., WULF-GOLDENBERG, A., WEIS, W. I., VON KRIES, J. P. & BIRCHMEIER, W. 2016. A Small-Molecule Antagonist of the beta-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis. Cancer Res, 76, 891-901.
  6. WEND, P., FANG, L., ZHU, Q., SCHIPPER, J. H., LODDENKEMPER, C., KOSEL, F., BRINKMANN, V., ECKERT, K., HINDERSIN, S., HOLLAND, J. D., LEHR, S., KAHN, M., ZIEBOLD, U. & BIRCHMEIER, W. 2013. Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J, 32, 1977-89.
  7. HOLLAND, J. D., GYORFFY, B., VOGEL, R., ECKERT, K., VALENTI, G., FANG, L., LOHNEIS, P., ELEZKURTAJ, S., ZIEBOLD, U. & BIRCHMEIER, W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep, 5, 1214-27.