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Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus

November 6, 2019|Research | 1 Min Read

Abstract Gene annotation is a critical resource in genomics research. Many computational approaches have been developed to assemble transcriptomes based on high-throughput short-read sequencing, however, only with limited accuracy. Here, […]

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A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

November 6, 2019|Research | 2 Min Read

Abstract Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we report the identification of a de novo heterozygous missense mutation in the […]

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A deep learning framework to predict binding preference of RNA constituents on protein surface

November 6, 2019|Research | 1 Min Read

Abstract Protein-RNA interaction plays important roles in post-transcriptional regulation. However, the task of predicting these interactions given a protein structure is difficult. Here we show that, by leveraging a deep […]

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