Wei Chen

Wei Chen

Chair Professor

Email

chenw@sustech.edu.cn

Phone

86 (0) 755-88018449

2
Book chapter
131
Peer-reviewed papers
56
H-index
16849
Cited times

Till 8/2019

EMPLOYMENT

2018-present        Chair, Department of biology, Southern University of Science and Technology (SUSTech)
2016-present        Vice dean, SUSTech Academy of Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech)
2016-2018             Director, Medi-X Institute, SUSTech Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech)
2016-present        Chair professor, Department of biology, Southern University of Science and Technology (SUSTech)
2015-2016             Full professor (W3), Max-Delbrueck-Center for Molecular Medicine jointly with Charité – Universitätsmedizin Berlin
2014-2016             Director, BIH genomics core
2009-2016            Group Leader, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany (Tenured since 2011)
2007-2009            Group Leader, MPI for Molecular Genetics, Berlin, Germany
2002-2006            Ph.D. student, MPI for Molecular Genetics, Berlin, Germany
1999-2002            Master student, Sichuan University, Chengdu, China
1993-1999             Research scientist, Sichuan University, Chengdu, China

EDUCATION

Ph.D.        Molecular Genetics        MPI for Molecular Genetics      October, 2006
M.S.          Medical Genetics            Sichuan University                     July, 2002
B.S.           Biochemistry                   Xiamen University                     July, 1993

AWARDS AND HONORS

2006               Scholarship for attending 47th Annual Short Course on Medical and Experimental Mammalian Genetics
2002-2006    Max-Planck Ph.D. student fellowship

EDITORIAL BOARD

2014-           Journal of Molecular Medicine
2018-           Life Science Alliance

RESEARCH FIELD

Systems biology, Functional and medical genomics, Bioinformatics, Precision medicine and individualized therapy.

REPRESENTATIVE PUBLICATIONS

  1. Xiao MS, Zhang B, Li YS, Gao Q, Sun W, Chen W. Global analysis of regulatory divergence in the evolution of mouse alternative polyadenylation. Mol Syst Biol. 2016 Dec 8;12(12):890. doi: 10.15252/msb.20167375.
  2. Chen W, Schuman E. Circular RNAs in Brain and Other Tissues: A Functional Enigma. Trends Neurosci. 2016 Jul 18. pii: S0166-2236(16)30069-8. doi: 10.1016/j.tins.2016.06.006. [Epub ahead of print]
  3. Wang X, Hou J, Quedenau C, Chen W. Pervasive isoform-specific translational regulation via alternative transcription start sites in mammals. (Cover story) Mol Syst Biol. 2016 Jul 18;12(7):875. doi: 10.15252/msb.20166941.
  4. Hou J, Wang X, McShane E, Zauber H, Sun W, Selbach M, Chen W. Extensive allele-specific translational regulation in hybrid mice. Mol Syst Biol. 2015 Aug 7;11(8):825. doi: 10.15252/msb.156240.
  5. Gao Q, Sun W, Ballegeer M, Libert C, Chen W.Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing. Mol Syst Biol. 2015 Jul 1;11(7):816. doi: 10.15252/msb.20145970.
  6. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci. 2015 Feb 25. doi: 10.1038/nn.3975.
  7. Wang, Y., Gogol-Döring, A., Hu, H., Fröhler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y. and Chen, W (2013) Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. 2013 doi: 10.1002/emmm.20130266
  8. Sun W, You X, Gogol-Döring A, He H, Kise Y, Sohn M, Chen T, Klebes A, Schmucker D, Chen W (2013) Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing. EMBO J. 2013 Jun 21. doi: 10.1038/emboj.2013.144. [Epub ahead of print]
  9. Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J*, Chen W*, Selbach M*. (2011) Global quantification of mammalian gene expression control Nature. 2011 May 19;473(7347):337-42
  10. Adamidi C, Wang Y, Gruen D, Mastrobuoni G, You X, Tolle D, Dodt M, Mackowiak SD, Gogol-Doering A, Oenal P, Rybak A, Ross E, Alvarado AS, Kempa S*, Dieterich C*, Rajewsky N*, Chen W * (2011) De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res 21(7):1193-200

On-going Grants

  1. Sino-German (NSFC-DFG) Cooperative Research Project: An integrated transcriptomic-proteomic landscape of temperature controlled alternative splicing（No. 31861133013）, 2019.01-2021.12, ￥1.33 million;
  2. National Natural Science Foundation of China: Genome-wide Pan-tissue analysis of allele-specific RNA alternative splicing regulation in hybrid mice (No. 31771443), 2018.01-2021.12, ￥0.6 million;
  3. Basic Research Grant from Science and Technology Innovation Commission of Shenzhen Municipal Government.: Systems Biology-based Pan-tissue Analysis of RNA Alternative Polyadenylation Regulatory Network (No. JCYJ20180504165804015), 2019.03-2022.03, ￥0.4 million;
  4. Basic Research Grant from Science and Technology Innovation Commission of Shenzhen Municipal Government.: Mechanistic Study of mRNA Alternative Splicing Deregulation in Brain Diseases (No. JCYJ20170307105752508),  2017.05-2019.05, ￥3 million;