![](http://chenlab.bio.sustech.edu.cn/wp-content/uploads/2019/11/5dc24c3230058df2.jpg)
Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus
Abstract Gene annotation is a critical resource in genomics research. Many computational approaches have been developed to assemble transcriptomes based on high-throughput short-read sequencing, however, only with limited accuracy. Here, […]
![](http://chenlab.bio.sustech.edu.cn/wp-content/uploads/2019/11/5dc24b19c4d1c488.png)
A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing
Abstract Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we report the identification of a de novo heterozygous missense mutation in the […]
![](http://chenlab.bio.sustech.edu.cn/wp-content/uploads/2019/11/5dc2454fc40e3481.jpg)
A deep learning framework to predict binding preference of RNA constituents on protein surface
Abstract Protein-RNA interaction plays important roles in post-transcriptional regulation. However, the task of predicting these interactions given a protein structure is difficult. Here we show that, by leveraging a deep […]